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The inhibitors of 3?-hydroxysteroid dehydrogenase, 0231A and 0231B, were being extracted in 2001 by Gräafe from the fermentation broth of Streptomyces sp. HKI0231. Meanwhile three?-hydroxysteroid dehydrogenase is definitely an enzyme connected with inflammatory processes, these compounds are favorable as key structures for anti-inflammatory agents

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